The innate immune system is the first line of defense involved in protecting against external pathogens and is crucial for survival. However, uncontrolled activation of the immune system can result in more damage than the factor that triggered them, causing atrophic scarring, chronic inflammation and even Systemic inflammation events such as Lupus, arthritis, Crohn’s disease or sepsis. Fortunately, there are neuronal mechanisms of inflammatory control which could be part of new therapeutic strategies to be studied for a better control of this type of pathologies. In the last decade, the cholinergic pathway has been described as part of the neuronal mechanisms that can be exogenous activated for the non-pharmacological control of inflammatory diseases, the aim of this review is to present the evidence in basic research and encourage the research in medical practice.
Resúmen
El sistema inmune innato es la primera línea de defensa involucrada en proteger contra agentes patógenos externos y es esencial para la supervivencia. Sin embargo, su activación descontrolada puede generar más daño que el factor que lo desencadenó, ocasionando cicatrizaciones atróficas, inflamación crónica e incluso inflamación sistémica como las observadas en Lupus, artritis, enfermedad de Crohn o sepsis. Afortunadamente existen medios de control inflamatorio, entre los que se encuentran los mecanismos neuronales, que podrían ser parte de nuevas estrategias terapéuticas a estudiar para un mejor dominio de este tipo de patologías. En la última década se ha descrito la vía colinérgica como parte de los mecanismos neuronales que pueden ser activados de manera exógena para el control no farmacológico de enfermedades inflamatorias. El propósito de esta revisión es exponer las evidencias en investigación básica sobre el tema y fomentar su estudio para la aplicación clínica.
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