Under normal conditions, the neutrophils are the leukocytes more abundant in the bloodstream, and these cells are a relevant part of the innate immune response. They are the first cells recruited to sites of injury or inflammation to eliminate and prevent the spread of pathogenic microorganisms or foreign agents immediately without depending on previous exposure. Neutrophils directly detect common structures conserved in pathogens through pattern recognition receptors (PRR) or facilitated by soluble molecules called opsonins. This recognizing activates the neutrophil effector functions, including phagocytosis, intracellular killing through phagolysosome formation, the release of antimicrobial granule contents by degranulation, or neutrophil extracellular traps (NET). This article describes the relevance of these cells in the immune response, highlighting the characteristics that make them “martyrs” as they are capable of dying faithful to their cause, protecting the body from infections.
Resúmen
Bajo condiciones normales, los neutrófilos son los leucocitos más abundantes en circulación sanguínea y forman parte de la respuesta inmune innata al ser las primeras células en reclutarse en los sitios de lesión o inflamación para eliminar y evitar la diseminación de microorganismos patógenos o agentes extraños de forma inmediata sin depender de una exposición previa. Principalmente al detectar estructuras comunes conservadas en patógenos de forma directa a través de los receptores de reconocimiento de patrones (PRR) o facilitado por moléculas solubles denominadas opsoninas, activando sus funciones efectoras que incluyen la fagocitosis con la destrucción intracelular a través del fagolisosoma, la liberación del contenido de los gránulos antimicrobianos por desgranulación y la formación de trampas extracelulares de neutrófilos (NET). En este artículo se describe la relevancia de estas células en la respuesta inmune resaltando sus características que los convierten en “los mártires” al ser capaces de morir fieles a su causa protegiendo al organismo de las infecciones.
Ene | Feb | Mar | Abr | May | Jun | Jul | Ago | Sept | Oct | Nov | Dic |
---|---|---|---|---|---|---|---|---|---|---|---|
- | - | - | - | - | - | - | - | - | - | - | 53 |
Ene | Feb | Mar | Abr | May | Jun | Jul | Ago | Sept | Oct | Nov | Dic |
---|---|---|---|---|---|---|---|---|---|---|---|
14 | 10 | 17 | 13 | 21 | 7 | 11 | 32 | 32 | 20 | 49 | 12 |
Ene | Feb | Mar | Abr | May | Jun | Jul | Ago | Sept | Oct | Nov | Dic |
---|---|---|---|---|---|---|---|---|---|---|---|
24 | 48 | 36 | 27 | 35 | - | - | - | - | - | - | - |
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